该基因编码一个富含AT的相互作用域(ARID)的DNA结合蛋白家族成员。 ARID家族的成员在胚胎模式,细胞谱系基因调控,细胞周期控制,转录调控和染色质结构修饰中发挥作用。 该蛋白作为多溴和BRG1相关因子或PBAF(SWI / SNF-B)染色质重塑复合物的亚基,通过核受体促进配体依赖性转录激活。 该基因的突变与肝细胞癌有关。 该基因的假基因位于第1号染色体上。 [由RefSeq提供,2016年12月]
This gene encodes a member of the AT-rich interactive domain (ARID)-containing family of DNA-binding proteins. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and chromatin structure modification. This protein functions as a subunit of the polybromo- and BRG1-associated factor or PBAF (SWI/SNF-B) chromatin remodeling complex which facilitates ligand-dependent transcriptional activation by nuclear receptors. Mutations in this gene are associated with hepatocellular carcinomas. A pseudogene of this gene is found on chromosome1. [provided by RefSeq, Dec 2016]

基因名:ARID2
别名:CSS6,p200,BAF200
基因ID:196528
Chromosome:
(GRCh37)
12 Start: 46123494 End: 46301820 Strand: 
信号通路: DNA修饰及其它