该基因编码Jumonji,富含AT的相互作用域1(JARID1)组蛋白脱甲基酶蛋白家族的成员。 编码的蛋白质通过组蛋白编码使组蛋白H3的赖氨酸4脱甲基,从而在基因调控中发挥作用。 编码的蛋白质与许多其他蛋白质(包括成视网膜细胞瘤蛋白质)相互作用,并与Hox基因和细胞因子的转录调控有关。 该基因可能在肿瘤进展中起作用。 [由RefSeq提供,2013年8月]
This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013]
 

基因名:KDM5A
别名:RBP2,RBBP2,RBBP-2
基因ID:5927
Chromosome:
(GRCh37)
12 Start: 389223 End: 498620 Strand: 
信号通路: 组蛋白修饰  能量代谢 
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