该基因编码的蛋白是ATP结合盒(ABC)转运蛋白的超家族成员。ABC蛋白通过细胞外膜和细胞内膜转运各种分子。ABC基因分为7个不同的亚家族(abc1,mdr/tap,mrp,ald,oabp,gcn20,white)。这种蛋白是MRP亚家族的一员,它与多药耐药有关。这种蛋白质的具体功能尚未确定;然而,这种蛋白质可能在有机阴离子的胆道和肠道排泄物的转运中起作用。另外,还描述了编码不同蛋白质亚型的剪接变体;然而,并非所有变体都具有完全特征。
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

基因名:ABCC3
别名:ABC31,EST90757,MLP2,MOAT-D,MRP3,cMOAT2
基因ID:8714
Chromosome:
(GRCh37)
17 Start: 48712138 End: 48769613 Strand: 1
信号通路:  
靶向药:
化疗药: 甲基澳瑞他汀 E 紫杉醇