由该基因编码的膜相关蛋白包含在ATP结合盒(ABC)转运子的超家族中。ABC蛋白通过细胞外膜和细胞内膜转运各种分子。ABC基因分为7个不同的亚家族(abc1,mdr/tap,mrp,ald,oabp,gcn20,white)。这种蛋白是白色亚家族的成员。或者称为乳腺癌抵抗蛋白,这种蛋白作为外源性转运蛋白发挥作用,可能在多药耐药中起主要作用。它可能是对米托蒽醌和蒽环类药物暴露的一种细胞防御机制。该蛋白在胎盘中有明显的表达,这可能提示该分子在胎盘组织中的潜在作用。已发现编码该基因不同亚型的多种转录变体。
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene.

基因名:ABCG2
别名:ABC15,ABCP,BCRP,BCRP1,BMDP,CD338,CDw338,EST157481,GOUT1,MRX,MXR,MXR-1,MXR1,UAQTL1
基因ID:9429
Chromosome:
(GRCh37)
4 Start: 89011416 End: 89152474 Strand: -1
信号通路: 能量代谢 
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