这个基因是一个假定的癌基因,编码一个属于丝氨酸/苏氨酸激酶亚家族的蛋白质,包含sh2样(SRC同源2样)结构域。该基因在8个卵巢癌细胞系中的2个和15个原发性卵巢肿瘤中的2个被扩增和过度表达。过度表达导致人导管胰腺癌亚群的恶性表型。编码蛋白是一种普通的蛋白激酶,能够对几种已知的蛋白进行磷酸化。
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.

基因名:AKT2
别名:HIHGHH,PKBB,PKBBETA,PRKBB,RAC-BETA
基因ID:208
Chromosome:
(GRCh37)
19 Start: 40736224 End: 40791443 Strand: -1
信号通路: 细胞增殖  免疫相关  炎症相关  血管生成  凋亡抑制  能量代谢 
靶向药: 依维莫司  曲妥珠单抗  凡德他尼 
化疗药:
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