这个基因编码的蛋白质是AKT的一个成员,也被称为pkb,丝氨酸/苏氨酸蛋白激酶家族。Akt激酶是已知的细胞信号调节器,对胰岛素和生长因子作出反应。参与多种生物学过程,包括细胞增殖、分化、凋亡、肿瘤发生以及糖原合成和葡萄糖摄取。这种激酶被血小板衍生生长因子(pdgf)、胰岛素和胰岛素样生长因子1(igf1)刺激。另外,还描述了编码不同亚型的剪接转录变体。
The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.

基因名:AKT3
别名:MPPH,MPPH2,PKB-GAMMA,PKBG,PRKBG,RAC-PK-gamma,RAC-gamma,STK-2
基因ID:10000
Chromosome:
(GRCh37)
1 Start: 243651535 End: 244014381 Strand: -1
信号通路: 细胞增殖  免疫相关  炎症相关  血管生成  凋亡抑制  能量代谢 
靶向药: AKT3 Inhibitor GSK690693  MK-2206  维莫非尼 
化疗药: