该基因编码的蛋白是一种细胞周期调节激酶,在染色体分离过程中似乎与纺锤体极的微管形成和/或稳定有关。编码蛋白存在于有丝分裂的间期细胞的中心体和纺锤体两极。该基因可能在肿瘤的发展和进展中起作用。在1号染色体上发现一个经过加工的假基因,在10号染色体上发现一个未经加工的假基因。已发现该基因的多个编码相同蛋白质的转录变体。
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.

基因名:AURKA
别名:AIK,ARK1,AURA,BTAK,PPP1R47,STK15,STK6,STK7
基因ID:6790
Chromosome:
(GRCh37)
20 Start: 54944445 End: 54967393 Strand: -1
信号通路: 细胞周期 
靶向药: Alisertib  PLATINUM 
化疗药: 氟尿嘧啶 顺铂 紫杉醇 他莫昔芬 
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