该基因编码IAP蛋白家族的一个成员,通过结合肿瘤坏死因子受体相关因子traf1和traf2抑制凋亡,可能通过干扰类冰蛋白酶的激活。编码的蛋白质抑制血清剥夺诱导的细胞凋亡,但不影响细胞凋亡,暴露于甲萘醌,一个强有力的诱导自由基。它包含3个杆状病毒IAP重复序列和一个环指域。编码相同亚型的转录变体已经被鉴定出来。
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified.

基因名:BIRC3
别名:AIP1,API2,CIAP2,HAIP1,HIAP1,MALT2,MIHC,RNF49,c-IAP2
基因ID:330
Chromosome:
(GRCh37)
11 Start: 102188215 End: 102210134 Strand: 1
信号通路: