该基因编码的蛋白质与小鼠蛋白MCAP(有丝分裂过程中与染色体相关)和人类Ring3蛋白(丝氨酸/苏氨酸激酶)同源。每一种蛋白质都包含两个溴域,一个保守的序列基序,可能参与染色质靶向。该基因被认为是T(15;19)易位的19号染色体靶基因(q13;p13.1),它定义了年轻人的上呼吸道癌。已经描述了两个选择性剪接转录变体。
The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described.

基因名:BRD4
别名:CAP,HUNK1,HUNKI,MCAP
基因ID:23476
Chromosome:
(GRCh37)
19 Start: 15347647 End: 15443356 Strand: -1
信号通路: 组蛋白修饰  细胞增殖 
靶向药: 比拉瑞塞  JQ1 
化疗药: