该基因编码E3泛素连接酶CBL家族的一个成员。cbl蛋白通过泛素化和随后的酪氨酸激酶下调在细胞信号传导中发挥重要作用。该基因的表达可能仅限于上皮细胞,而且还观察到该基因编码多种亚型的选择性剪接转录变体。
This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

基因名:CBLC
别名:CBL-3,CBL-SL,RNF57
基因ID:23624
Chromosome:
(GRCh37)
19 Start: 45281126 End: 45303891 Strand: 1
信号通路:  
靶向药: 奥拉帕利 
化疗药:
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