该基因编码的蛋白质是一种参与细胞间相互作用、细胞粘附和迁移的细胞表面糖蛋白。它是透明质酸(ha)的受体,也可以与其他配体相互作用,如骨桥蛋白、胶原和基质金属蛋白酶(mmps)。该蛋白参与多种细胞功能,包括淋巴细胞活化、循环和归巢、造血和肿瘤转移。该基因的转录产物经过复杂的选择性剪接,导致许多功能上不同的亚型,然而,还没有确定其中一些变体的全长性质。选择性剪接是该蛋白结构和功能多样性的基础,可能与肿瘤转移有关。
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.

基因名:CD44
别名:CDW44,CSPG8,ECMR-III,HCELL,HUTCH-I,IN,LHR,MC56,MDU2,MDU3,MIC4,Pgp1
基因ID:960
Chromosome:
(GRCh37)
11 Start: 35160417 End: 35253949 Strand: 1
信号通路:  
靶向药: RG7356 
化疗药: