该基因编码的蛋白是一种细胞凋亡调节因子,其结构与caspase-8相似。然而,编码蛋白缺乏半胱天冬酶活性,似乎自己被半胱天冬酶8分裂成两个肽。该基因有几种编码不同亚型的转录变体,并且存在更多变体的部分证据。
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists.

基因名:CFLAR
别名:CASH,CASP8AP1,CLARP,Casper,FLAME,FLAME-1,FLAME1,FLIP,I-FLICE,MRIT,c-FLIP,c-FLIPL,c-FLIPR,c-FLIPS
基因ID:8837
Chromosome:
(GRCh37)
2 Start: 201980827 End: 202041410 Strand: 1
信号通路:  
靶向药:
化疗药: 比卡鲁胺 
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