该基因编码一个包含sh2和sh3(SRC同源)结构域的蛋白激酶,该结构域已被证明激活ras和jun激酶信号通路并以ras依赖的方式转化成纤维细胞。是bcr-abl酪氨酸激酶的底物,在bcr-abl的成纤维细胞转化中起作用,可能致癌。
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.

基因名:CRKL
别名:
基因ID:1399
Chromosome:
(GRCh37)
22 Start: 21271714 End: 21308037 Strand: 1
信号通路: 细胞增殖 
靶向药: 达沙替尼  吉非替尼 
化疗药: