这个基因编码一种属于Dickkopf家族的蛋白质。是一种具有两个富含半胱氨酸区域的分泌蛋白,通过抑制Wnt信号通路参与胚胎发育。骨髓血浆和外周血中dkk1水平升高与多发性骨髓瘤患者存在溶骨性骨病变有关。
This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

基因名:DKK1
别名:DKK-1,SK
基因ID:22943
Chromosome:
(GRCh37)
10 Start: 54074056 End: 54077802 Strand: 1
信号通路:  
靶向药: L-Folinic Acid 
化疗药: 氟尿嘧啶 伊立替康 奥沙利铂