CpG甲基化是一种表观遗传修饰,对胚胎发育、印记和X染色体失活具有重要意义。对小鼠的研究表明,DNA甲基化是哺乳动物发育所必需的。这个基因编码一种DNA甲基转移酶,被认为在从头甲基化中起作用,而不是维持甲基化。该蛋白定位于细胞质和细胞核,其表达受发育调节。
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.

基因名:DNMT3A
别名:DNMT3A2,M.HsaIIIA,TBRS
基因ID:1788
Chromosome:
(GRCh37)
2 Start: 25455845 End: 25565459 Strand: -1
信号通路: DNA修饰及其它  能量代谢 
靶向药: 阿特朱单抗  Decitabine 纳武单抗(纳武利尤单抗)  派姆单抗(帕博利珠单抗) 
化疗药: 柔红霉素 伊达比星