肾上腺素受体及其配体,肾上腺素,介导许多发育过程,特别是在神经系统。根据其结构和序列关系,肾素被分为通过糖基磷脂酰肌醇连接锚定在膜上的肾素-A(efna)类和作为跨膜蛋白的肾素-B(efnb)类。EPH受体家族根据其胞外结构域序列的相似性及其与肾素A和肾素B配体结合的亲缘关系分为2组。肾上腺素受体构成受体酪氨酸激酶(RTK)家族的最大亚群。该基因编码的蛋白质与肾素B2结合,在血管发育中起重要作用。
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.

基因名:EPHB4
别名:HTK,MYK1,TYRO11
基因ID:2050
Chromosome:
(GRCh37)
7 Start: 100400187 End: 100425121 Strand: -1
信号通路:  
靶向药: 贝伐单抗 
化疗药: