该基因编码一个包含ets DNA结合域的转录因子。该基因可以与位于染色体22上的尤因肉瘤基因进行T(11;22)(q24;q12)易位,从而导致大多数尤因肉瘤病例中存在融合基因。一个急性淋巴母细胞白血病相关的T(4;11)(q21;q23)易位涉及这个基因也被确认。选择性剪接导致多个转录变体。
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants.

基因名:FLI1
别名:EWSR2,SIC-1
基因ID:2313
Chromosome:
(GRCh37)
11 Start: 128556430 End: 128683162 Strand: 1
信号通路: