该基因属于叉头盒转录因子家族的P亚科。叉头盒转录因子在发育和成年期间对组织和细胞类型特异性基因转录的调节中起着重要作用。叉头盒P1蛋白包含DNA结合域和蛋白质结合域。该基因可能作为肿瘤抑制因子发挥作用,因为它在多种肿瘤类型中丢失,并映射到据报道含有肿瘤抑制基因的染色体区域(3P14.1)。选择性剪接导致编码不同亚型的多个转录变体。
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.

基因名:FOXP1
别名:12CC4,HSPC215,MFH,QRF1,hFKH1B
基因ID:27086
Chromosome:
(GRCh37)
3 Start: 71003844 End: 71633140 Strand: -1
信号通路: 肿瘤干细胞