该基因产物属于组蛋白脱乙酰基酶家族。组蛋白脱乙酰基酶通过形成大的多蛋白复合物起作用,并负责核心组蛋白(H2A、H2B、H3和H4)N端赖氨酸残基的脱乙酰化。这种蛋白通过与许多不同的蛋白质结合形成转录抑制复合物,包括哺乳动物锌指转录因子YY1。因此,它在转录调控、细胞周期进展和发育事件中起着重要作用。选择性剪接导致多个转录变体。
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.

基因名:HDAC2
别名:HD2,RPD3,YAF1
基因ID:3066
Chromosome:
(GRCh37)
6 Start: 114254192 End: 114332472 Strand: -1
信号通路: 组蛋白修饰  细胞周期  肿瘤干细胞 
靶向药: 艾贝司他  培唑帕尼 
化疗药: