这个基因编码MAP激酶家族的一个成员。MAP激酶又称细胞外信号调节激酶(ERK),是多种生化信号的整合点,参与多种细胞过程,如增殖、分化、转录调控和发育。这种激酶的激活需要上游激酶的磷酸化。激活后,这种激酶转移到受刺激细胞的细胞核,在那里磷酸化核靶。一项研究还表明,这种蛋白作为一种转录抑制因子独立于其激酶活性。编码蛋白被鉴定为一种月光蛋白,基于其执行机械上不同功能的能力。两个选择性剪接的转录变异体编码相同的蛋白质,但不同的UTR,已报告这个基因。
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

基因名:MAPK1
别名:ERK,ERK-2,ERK2,ERT1,MAPK2,P42MAPK,PRKM1,PRKM2,p38,p40,p41,p41mapk,p42-MAPK
基因ID:5594
Chromosome:
(GRCh37)
22 Start: 22108789 End: 22221970 Strand: -1
信号通路: 细胞增殖 
靶向药: 厄洛替尼  WZ4002 
化疗药: