该基因编码的蛋白质是一种多功能的核磷蛋白,在细胞周期进展、凋亡和细胞转化中起到作用。作为调节特定靶基因转录的转录因子发挥作用。这种基因的突变、过度表达、重排和易位与多种造血肿瘤、白血病和淋巴瘤,包括伯基特淋巴瘤有关。有证据表明,来自上游、非aug(cug)帧和下游aug起始位点的选择性翻译起始导致两种具有不同N末端的亚型的产生。在伯基特淋巴瘤中,非aug启动蛋白的合成受到抑制,这表明它在该基因正常功能中的重要性。
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.

基因名:MYC
别名:MRTL,MYCC,bHLHe39,c-Myc
基因ID:4609
Chromosome:
(GRCh37)
8 Start: 128747680 End: 128753674 Strand: 1
信号通路: 细胞增殖  细胞周期  炎症相关  能量代谢  肿瘤干细胞 
靶向药: 伊布替尼  JQ1  奥拉帕利  Prexasertib 
化疗药: 顺铂 
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