这个基因是myc家族的一员,编码一个具有基本螺旋-环-螺旋(bhlh)结构域的蛋白质。这种蛋白位于细胞核内,必须与另一种bhlh蛋白二聚以结合DNA。这种基因的扩增与多种肿瘤有关,尤其是神经母细胞瘤。该基因有多种编码不同亚型的选择性剪接转录变体。
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

基因名:MYCN
别名:MODED,N-myc,NMYC,ODED,bHLHe37
基因ID:4613
Chromosome:
(GRCh37)
2 Start: 16080686 End: 16087129 Strand: 1
信号通路: 凋亡抑制  肿瘤干细胞 
靶向药: CBL0137  GSK126  JQ1 JQEZ5 比拉瑞塞  帕比司他  索尼德吉 
化疗药: 三氧化二砷 
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