该基因编码的蛋白作为核激素受体(包括类固醇、甲状腺、类视黄醇和维生素D受体)的转录辅活化因子发挥作用。编码蛋白作为这些核受体配体依赖性活性的中间因子,通过同源反应元件的结合来调节其靶基因。该基因被发现与导致与各种癌症的其他基因融合的易位有关,包括急性髓细胞性白血病的赖氨酸乙酰转移酶6a(kat6a)基因、急性淋巴细胞性白血病的ets变异体6(etv6)基因以及在肿瘤中含有YRPW基序1(hey1)基因的hes相关家族bhlh转录因子。间充质软骨肉瘤。选择性剪接导致多个转录变体。
The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants.

基因名:NCOA2
别名:GRIP1,KAT13C,NCoA-2,SRC2,TIF2,bHLHe75
基因ID:10499
Chromosome:
(GRCh37)
8 Start: 71021997 End: 71316040 Strand: -1
信号通路: