这个位点编码一个ATP依赖染色质重塑复合物的亚单位。编码蛋白被鉴定为核激素受体激活配体依赖性转录所必需的复合物的组成部分。该位点的突变与原发性透明细胞肾细胞癌有关。
This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma.

基因名:PBRM1
别名:BAF180,PB1
基因ID:55193
Chromosome:
(GRCh37)
3 Start: 52579368 End: 52719933 Strand: -1
信号通路: 基因组不稳定 
靶向药: 阿特朱单抗  巴文西亚  Durvalumab  CTLA-4 Inhibitor 依维莫司  伊匹单抗  PD-L1 Antibody 派姆单抗(帕博利珠单抗)  纳武单抗(纳武利尤单抗) 
化疗药: