该基因编码的蛋白属于SER/THR蛋白激酶家族和PIM亚家族。该基因主要在B淋巴细胞和骨髓细胞系中表达,在造血恶性肿瘤和前列腺癌中过表达。在血细胞信号转导中起作用,有助于细胞增殖和存活,从而在肿瘤发生中提供选择性优势。据报道,人类和正常小鼠的基因都编码两种亚型(具有优先的细胞定位),这两种亚型是由于在帧翻译起始密码子中使用了替代的,即上游非aug(cug)和下游aug密码子(pmids:161868051825810)。
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).

基因名:PIM1
别名:PIM
基因ID:5292
Chromosome:
(GRCh37)
6 Start: 37137979 End: 37143202 Strand: 1
信号通路: