该基因编码DNA聚合酶δ的125kDa催化亚单位。DNA聚合酶三角洲既具有聚合酶活性,又具有3-5'外切酶活性,在DNA复制和修复中起着关键作用。另外还观察到该基因的剪接转录变体,该基因的假基因位于6号染色体的长臂上。
This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6.

基因名:POLD1
别名:CDC2,CRCS10,MDPL,POLD
基因ID:5424
Chromosome:
(GRCh37)
19 Start: 50887461 End: 50921273 Strand: 1
信号通路: 细胞周期  基因组不稳定  能量代谢  遗传相关 
靶向药: 派姆单抗(帕博利珠单抗) 
化疗药:
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