这个基因是一组基因的一员,在紧张的生长停滞状态和用DNA破坏剂治疗后,这些基因的转录水平会增加。无论p53的状态如何,电离辐射对该基因的诱导都发生在某些细胞系中,其蛋白反应与电离辐射后细胞凋亡有关。
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation.

基因名:PPP1R15A
别名:GADD34
基因ID:23645
Chromosome:
(GRCh37)
19 Start: 49375649 End: 49379314 Strand: 1
信号通路:  
靶向药: 贝伐单抗  FOLFIRI Regimen 
化疗药: