蛋白激酶C(PKC)是一个丝氨酸和苏氨酸特异性蛋白激酶家族,可被钙和第二信使二酰甘油激活。pkc家族成员磷酸化多种蛋白质靶点,已知参与多种细胞信号传导途径。PKC家族成员也作为一类肿瘤启动子佛波酯的主要受体。pkc家族的每一个成员都有一个特定的表达谱,并且被认为在细胞中起着独特的作用。该基因编码的蛋白质是pkc家族成员之一。据报道,这种蛋白激酶参与多种不同的细胞功能,如B细胞活化、凋亡诱导、内皮细胞增殖和肠道糖吸收。对小鼠的研究也表明,这种激酶还可能调节神经元功能,并与压力后恐惧诱导的冲突行为相关。另外还报道了编码不同亚型的剪接转录变体。
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

基因名:PRKCB
别名:PKC-beta,PKCB,PRKCB1,PRKCB2
基因ID:5579
Chromosome:
(GRCh37)
16 Start: 23847322 End: 24231932 Strand: 1
信号通路: