26S蛋白酶体是一种多催化蛋白酶复合物,由2个复合物、一个20S核和一个19S调节器组成,具有高度有序的结构。20S核由4个28个不相同亚单位的环组成,2个环由7个α亚单位组成,2个环由7个β亚单位组成。19S调节器由一个碱基(包含6个ATPase亚单位和2个非ATPase亚单位)和一个LID(包含10个非ATPase亚单位)组成。蛋白酶体以高浓度分布于真核细胞,并在非溶酶体途径的ATP/泛素依赖过程中分裂肽。经修饰的蛋白酶体免疫蛋白酶体的一个基本功能是加工I类mhc肽。这个基因编码19S调节盖的一个非ATP酶亚单位。在10号和21号染色体上发现了假基因。
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21.

基因名:PSMD4
别名:AF,AF-1,ASF,MCB1,Rpn10,S5A,pUB-R5
基因ID:5710
Chromosome:
(GRCh37)
1 Start: 151227179 End: 151239955 Strand: 1
信号通路:  
靶向药: 卡非佐米  Talazoparib 
化疗药: