该基因编码的蛋白是蛋白酪氨酸磷酸酶(PTP)家族的成员。PTP是调节多种细胞过程的信号分子,包括细胞生长、分化、有丝分裂周期和致癌转化。这个ptp包含一个c-末端害虫基序,作为一个蛋白质-蛋白质相互作用域,可以调节蛋白质的细胞内半衰期。这种PTP被发现与癌基因c-abl的产物结合并去磷酸化,因此可能在肿瘤发生中起作用。这种PTP还显示与细胞骨架结构和细胞粘附相关的各种产物,如p130(cas)、cakbeta/ptk2b、pstpip1和paxillin相互作用和去磷酸化。这表明它在控制细胞形状和流动性方面具有调节作用。选择性剪接导致编码不同亚型的多个转录变体。
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

基因名:PTPN12
别名:PTP-PEST,PTPG1
基因ID:5782
Chromosome:
(GRCh37)
7 Start: 77166592 End: 77269388 Strand: 1
信号通路:  
靶向药: 克唑替尼  舒尼替尼 
化疗药: