该基因编码的蛋白是蛋白酪氨酸磷酸酶(PTP)家族的成员。众所周知,PTP是调节多种细胞过程的信号分子,包括细胞生长、分化、有丝分裂周期和致癌转化。该PTP包含一个胞外结构域、一个跨膜段和一个胞质内催化结构域,因此属于受体型PTP。该PTP的细胞外区由多个纤维连接蛋白Ⅲ型重复序列组成,该重复序列与神经受体和细胞粘附分子(如contactin和tenasin c)相互作用。该蛋白也与钠通道相互作用,因此可以通过改变酪氨酸磷酸化状态来调节钠通道。这种蛋白的相互作用伙伴的功能与PTP在细胞粘附、神经突生长和神经元分化中的作用有关。已发现该基因编码不同亚型的替代转录变体。
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene.

基因名:PTPRB
别名:HPTP-BETA,HPTPB,PTPB,R-PTP-BETA,VEPTP
基因ID:5787
Chromosome:
(GRCh37)
12 Start: 70910630 End: 71031220 Strand: -1
信号通路:  
靶向药: 舒尼替尼 
化疗药: