该基因编码的蛋白是蛋白酪氨酸磷酸酶(PTP)家族的成员。众所周知,PTP是调节多种细胞过程的信号分子,包括细胞生长、分化、有丝分裂周期和致癌转化。该PTP包含一个细胞外区、一个单跨膜段和两个串联胞质内催化域,因此代表一种受体型PTP。该蛋白的细胞外区由三个免疫球蛋白样结构域和八个纤维连接蛋白III型结构域组成。对鸡和苍蝇的相似基因的研究表明,这种PTP在促进轴突生长和调节神经元轴突引导中的作用。该基因的多种选择性剪接转录变体已被报道。在5号染色体上发现了一个相关的假基因。
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5.

基因名:PTPRD
别名:HPTP,HPTPD,HPTPDELTA,PTPD,RPTPDELTA
基因ID:5789
Chromosome:
(GRCh37)
9 Start: 8314246 End: 10612723 Strand: -1
信号通路: 细胞增殖 
靶向药: 西妥木单抗  JSI-124 R1507 
化疗药:
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