这个基因编码的蛋白质是RAD51蛋白家族的一员。Rad51家族成员与细菌Reca和酿酒酵母Rad51非常相似,已知它们参与同源重组和DNA修复。这种蛋白与RAD51家族的其他几个成员形成复合物,包括RAD51L1、RAD51L2和XRCC2。与该蛋白形成的蛋白复合物已被证明催化单链和双链DNA之间的同源配对,并被认为在DNA重组修复的早期阶段起到作用。选择性剪接导致多个转录变体。该基因与下游环指及含1(RFFL)基因的FYVE样结构域之间也存在着通读转录。
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene.

基因名:RAD51D
别名:BROVCA4,R51H3,RAD51L3,TRAD
基因ID:5892
Chromosome:
(GRCh37)
17 Start: 33426811 End: 33448541 Strand: -1
信号通路: 基因组不稳定  遗传相关 
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