这个基因编码核糖核苷酸还原酶的大的催化亚单位,这是一种将核糖核苷酸转化为脱氧核糖核苷酸所必需的酶。在细胞周期的S阶段以及多个DNA修复过程中,可用的脱氧核糖核苷酸池对DNA复制很重要。选择性剪接导致多个转录变体。
This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants.

基因名:RRM1
别名:R1,RIR1,RR1
基因ID:6240
Chromosome:
(GRCh37)
11 Start: 4115937 End: 4160106 Strand: 1
信号通路:  
靶向药: Cisplatine PLATINUM 
化疗药: 顺铂 多西他赛 吉西他滨 吉西他滨 顺铂 紫杉醇 长春瑞滨 
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