这个基因编码sirtuin蛋白家族的一个成员,与酵母sir2蛋白同源。sirtuin家族成员以sirtuin核心域为特征,分为四类。人类sirtuin的功能尚未确定;然而,已知酵母sirtuin蛋白可调节表观遗传基因沉默和抑制RDNA的重组。研究表明,人sirtuins可能作为具有单ADP核糖转移酶活性的细胞内调节蛋白发挥作用。该基因编码的蛋白质包含在sirtuin家族的I类中。选择性剪接导致多个转录变体。
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

基因名:SIRT1
别名:SIR2,SIR2L1,SIR2alpha
基因ID:23411
Chromosome:
(GRCh37)
10 Start: 69644427 End: 69678147 Strand: 1
信号通路:  
靶向药:
化疗药: 烟酰胺