该基因编码有机阴离子转运蛋白家族的肝特异性成员。编码蛋白是一种跨膜受体,介导许多内源性化合物(包括胆红素、17β-葡萄糖醛酸雌二醇和白三烯C4)的钠依赖性摄取。这种蛋白也参与从血液中去除药物化合物,如他汀类、溴磺基邻苯二甲酸和利福平,进入肝细胞。编码这种蛋白的基因多态性与转运蛋白功能受损有关。
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function.

基因名:SLCO1B1
别名:HBLRR,LST-1,LST1,OATP-C,OATP1B1,OATP2,OATPC,SLC21A6
基因ID:10599
Chromosome:
(GRCh37)
12 Start: 21284136 End: 21392180 Strand: 1
信号通路:  
靶向药:
化疗药: 甲氨蝶呤