这个基因编码一种属于芽科的蛋白质。编码蛋白含有一个羧基末端富含半胱氨酸的结构域,对受体酪氨酸激酶信号蛋白的抑制活性至关重要,并且对于生长因子刺激的蛋白质向膜皱褶的易位是必需的。在原发性真皮内皮细胞中,该基因对成纤维细胞生长因子2的反应是短暂上调的。该蛋白间接参与了对成纤维细胞生长因子2信号传导的非细胞自主抑制作用。该蛋白与cas-br-m(小鼠)电逆转录病毒转化序列相互作用,可作为表皮生长因子受体/丝裂原活化蛋白激酶信号的双峰调节器。该蛋白可能在肺发育过程中的肺泡分支中起作用,如小鼠蛋白所示。
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.

基因名:SPRY2
别名:IGAN3,hSPRY2
基因ID:10253
Chromosome:
(GRCh37)
13 Start: 80910111 End: 80915086 Strand: -1
信号通路:  
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