刺猬信号通路在人类早期发育中起着重要作用。该通路是一个信号级联,在发育过程中起到模式形成和细胞增殖的作用。这个基因编码了刺猬信号通路的负调节因子。这个基因的缺陷是髓母细胞瘤的原因。选择性剪接导致多个转录变体。
The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.

基因名:SUFU
别名:PRO1280,SUFUH,SUFUXL
基因ID:51684
Chromosome:
(GRCh37)
10 Start: 104263744 End: 104393292 Strand: 1
信号通路: 肿瘤干细胞 
靶向药: 索尼德吉 
化疗药: