该基因编码一个非受体型酪氨酸蛋白激酶家族成员。这种蛋白在造血细胞中广泛表达,并参与将激活的免疫受体与介导多种细胞反应(包括增殖、分化和吞噬)的下游信号事件耦合。它被认为是上皮细胞生长的调节剂和潜在的肿瘤抑制因子。另外,还发现了编码不同亚型的剪接转录变体。
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

基因名:SYK
别名:p72-Syk
基因ID:6850
Chromosome:
(GRCh37)
9 Start: 93564069 End: 93660831 Strand: 1
信号通路: 细胞增殖  免疫相关 
靶向药:
化疗药: 紫杉醇