该基因编码一种定位于核仁的转录终止因子,在核糖体基因转录中起关键作用。编码蛋白通过与前rRNA编码区下游的sal盒终止因子结合来介导RNA聚合酶I转录的终止。另外,还观察到该基因编码多种亚型的剪接转录变体。该基因与另一个基因NK2同源盒1(也称为甲状腺转录因子1)共享符号/别名“tff1”,后者在甲状腺特异性基因表达的调节中起作用。
This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression.

基因名:TTF1
别名:TTF-1,TTF-I
基因ID:7270
Chromosome:
(GRCh37)
9 Start: 135251008 End: 135282209 Strand: -1
信号通路:  
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