该基因属于基因的剪接因子SR家族。u2辅助因子包括一个大的和一个小的亚单位,是一种非snrnp蛋白,它是u2 snrnp结合到pre-mrna分支位点所必需的。该基因编码小亚单位,通过直接介导大亚单位和与增强子结合的蛋白质之间的相互作用,在组成和增强子依赖的RNA剪接中起关键作用。另外,还发现了编码不同亚型的剪接转录变体。
This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.

基因名:U2AF1
别名:FP793,RN,RNU2AF1,U2AF35,U2AFBP
基因ID:7307
Chromosome:
(GRCh37)
21 Start: 44513066 End: 44527697 Strand: -1
信号通路: 基因组不稳定 
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