该基因编码一种核蛋白,这是一种属于SER/THR蛋白激酶家族的酪氨酸激酶。这种蛋白催化CDC2/cyclin B激酶的抑制性酪氨酸磷酸化,并似乎通过保护细胞核免受细胞质激活的CDC2激酶的影响来协调DNA复制和有丝分裂之间的转换。
This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.

基因名:WEE1
别名:WEE1A,WEE1hu
基因ID:7465
Chromosome:
(GRCh37)
11 Start: 9595228 End: 9615004 Strand: 1
信号通路: 细胞增殖 
靶向药: AZD1775  PLATINUM 
化疗药: 吉西他滨