这个基因编码河马信号通路的下游核效应器,它参与发育、生长、修复和体内平衡。已知该基因在多种癌症的发展和进展中发挥作用,作为该信号通路的转录调节因子,并可能作为癌症治疗的潜在靶点发挥作用。选择性剪接导致编码不同亚型的多个转录变体。
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms.

基因名:YAP1
别名:COB1,YAP,YAP2,YAP65,YKI
基因ID:10413
Chromosome:
(GRCh37)
11 Start: 101981192 End: 102104154 Strand: 1
信号通路:  
靶向药:
化疗药: 氟尿嘧啶 多西他赛 维替泊芬 
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